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299 Uric acid deposition-induced inflammation, resulting in endothelial dysfunction and vascular damage (referred to as vascular gout), can occur at serum uric acid levels exceeding 6.5 mg/dL

Front Neuroanat (2015) 9:91.10.3389/fnana.2015.00091 6 BoscoDAFowlerDMZhangQNievaJPowersETWentworthPet alElevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization

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However, Hebbian-type plasticity rules introduce an intrinsic positive feedback on synaptic weight changes, making synapses prone to runaway potentiation or depression and eventual saturation, and making neuronal activity prone to runaway activation or complete silencing